What intervention is essential before the nurse administers tenecteplase (TNKase)?

• A. Perform all necessary venipunctures.
• B. Administer aminocaproic acid (Amicar).
• C. Have the client void.
• D. Assess for allergies to iodine.

Answer: (A)

Establishing reliable venous access before giving a thrombolytic like tenecteplase is essential because the drug is delivered rapidly through an IV bolus and you may need quick access to draw blood for baseline labs or to respond to any bleeding complications. Having IV lines in place prevents delays in administration, which is critical for dissolving the clot quickly and improving outcomes in acute MI.

Administering aminocaproic acid beforehand would counteract the intended effect of the thrombolytic and is not appropriate pre-treatment. Having the client void or assessing iodine allergy are not required steps directly related to preparing for thrombolytic therapy.