The nurse is teaching a client about clopidogrel (Plavix). What is important information to include?

• A. Constipation may occur.
• B. Hypotension may occur.
• C. Bleeding may increase when taken with aspirin.
• D. Normal dose is 25 mg tablet per day.

Answer: (C)

Bleeding risk with antiplatelet therapy is what this item emphasizes. Clopidogrel blocks the P2Y12 ADP receptor on platelets, preventing platelet aggregation. When it’s used with aspirin, two drugs that impair platelet function, the chance of unexpected or prolonged bleeding increases. That’s why patient teaching should highlight signs of bleeding (easy bruising, gum or nosebleeds, blood in stool or urine) and the importance of avoiding or limiting other bleeding-promoting medications unless directed by a clinician.

It’s also useful to know the usual dosing context: the common maintenance dose is 75 mg daily, so a 25 mg daily dose is not standard. Constipation or hypotension are not typical concerns with clopidogrel therapy.